Bioinformatics

minimap2 – versatile sequence alignment program

minimap2 is a versatile sequence alignment program for genomic and spliced nucleotide sequences.

This software aligns DNA or mRNA sequences against a large reference database and is designed for mapping, overlap detection, splice-aware alignment, and assembly or genome alignment tasks.

This is free and open source software.

Key Features

  • Aligns DNA or mRNA sequences against a large reference database.
  • Supports mapping of genomic long reads from PacBio and Oxford Nanopore technologies.
  • Finds overlaps between long reads.
  • Provides splice-aware alignment for long reads and cDNA against a reference genome.
  • Supports alignment of full-length cDNA or mRNA sequences against a reference genome.
  • Supports alignment of genomic short reads from Illumina platforms.
  • Supports assembly-to-reference alignment.
  • Supports full-genome alignment between closely related species.
  • Outputs approximate mappings in PAF format.
  • Outputs base-level alignments in SAM format.

Website: github.com/lh3/minimap2
Support:
Developer: Heng Li
License: MIT License

minimap2 is written in C. Learn C with our recommended free books and free tutorials.


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Read our verdict in the software roundup.


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