(commercial) aiCache is a tool for predicting a program's intrinsic instruction cache behavior. In other words, aiCache classifies most references to the instruction memory (instruction fetches) as cache hits or misses.
BuGLe combines a graphical OpenGL debugger with a selection of filters on the OpenGL command stream. The debugger allows viewing of state, textures, framebuffers and shaders, while the filters allow for logging, error checking, video capture and more.
Deet is a graphical debugger which can be easily retargetted to different languages, compilers, operating systems, etc. It does so by separating core debugger functionality from user interface. All debugger functionality is implemented with a small set of commands, called a nub.
EDB (Evan's Debugger) is a QT4 based binary mode debugger with the goal of having usability on par with OllyDbg. It uses a plugin architecture, so adding new features can be done with ease.
a Python GUI utility for creating, testing and debugging regular expressions for the Python programming language. Kodos should aid any developer to efficiently and effortlessly develop regular expressions in Python
LDasm is a Perl/Tk-based GUI for objdump/binutils that tries to imitate the look'n'feel of W32Dasm. It searchs for cross-references (e.g. strings), converts the code from GAS to a MASM-like style and more.
(commercial) NightStar is a suite of debugging and analysis tools for Linux software development. NightStar tools are minimally intrusive, allowing users to locate bugs, find timing bottlenecks, and analyze multi-threaded and multi-process interactions while preserving application execution behavior and determinism. NightStar includes a complete source-level debugger, a trace utility that offers a graphic view of kernel interactions, a data monitor, and a system and application performance tuner.
perldbgui is a GUI for the perl debugger. The GUI actually runs in a separate process from the debugger itself. The debugger is the Perl debugger hacked a bit to use the IPC::Open2 module to talk to the GUI.
TkGnats is a Tcl/Tk-based front end for the GNATS bug management system.
(commercial) ZeroBUGS is a C++ application debugger for Linux. The debugger is written from scratch in C++, it has a modular architecture and can be scripted using the Python language.
It supports multi-threading, and has experimental support for the Digital Mars D Programming Language.